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What the FDA labels say about taking them together

Danazol and glimepiride

Glimepiride's FDA label of May 12, 2025 names danazol in its drug interactions section; the danazol label PlainMeds reads does not name glimepiride. The glimepiride label: “The following are examples of medications that may reduce the glucose-lowering effect of sulfonylureas including glimepiride, leading to worsening glycemic control: danazol, glucagon, somatropin, protease inhibitors …”

Check it at the source: the danazol FDA label on DailyMed (effective April 30, 2020, Lannett Company, Inc.); the glimepiride FDA label on DailyMed (effective May 12, 2025, Micro Labs Limited).

What does the danazol label say about glimepiride?

Danazol's label (effective April 30, 2020) does not name glimepiride in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (Danazol), Lannett Company, Inc., effective April 30, 2020 (SPL set f2c9b713-aafc-49ca-866e-334d9b5c2e2d), via openFDA; the full label on DailyMed

What does the glimepiride label say about danazol?

Glimepiride label, drug interactions

The following are examples of medications that may reduce the glucose-lowering effect of sulfonylureas including glimepiride, leading to worsening glycemic control: danazol, glucagon, somatropin, protease inhibitors, atypical antipsychotic medications (e.g., olanzapine and clozapine), barbiturates, diazoxide, laxatives, rifampin, thiazides and other diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics (e.g., epinephrine, albuterol, terbutaline), and isoniazid.

Source: FDA drug label (Glimepiride), Micro Labs Limited, effective May 12, 2025 (SPL set 60e9397e-83b9-489e-9683-6f87e458bbaa), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

4Danazol generic labelers
27Glimepiride generic labelers
DanazolGlimepiride
Labeled forn/aType 2 diabetes
Boxed warningYesNo
Pharmacy cost (NADAC)$2.65 per capsule 200 mg capsule$0.0507 per tablet 4 mg tablet
Shortage nowNo current entryNo current entry

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

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