What the FDA labels say about taking them together
Cytarabine and digoxin
Cytarabine's FDA label of April 7, 2025 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name cytarabine. The cytarabine label: “Drug Interactions Reversible decreases in steady-state plasma digoxin concentrations and renal glycoside excretion were observed in patients receiving beta-acetyldigoxin and chemotherapy regimens containing …”
Check it at the source: the cytarabine FDA label on DailyMed (effective April 7, 2025, Hospira, Inc.); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the cytarabine label say about digoxin?
Cytarabine label, drug interactionsDrug Interactions Reversible decreases in steady-state plasma digoxin concentrations and renal glycoside excretion were observed in patients receiving beta-acetyldigoxin and chemotherapy regimens containing cyclophosphamide, vincristine and prednisone with or without cytarabine injection or procarbazine.
Source: FDA drug label (Cytarabine), Hospira, Inc., effective April 7, 2025 (SPL set e3a8c0e9-19ed-49b7-8464-11e8806f47fd), via openFDA; the full label on DailyMed
What does the digoxin label say about cytarabine?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name cytarabine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cytarabine | Digoxin | |
|---|---|---|
| Labeled for | Leukemia, lymphoma and myeloma | Heart failure, Atrial fibrillation |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | n/a | $0.133 per tablet 125 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once