What the FDA labels say about taking them together
Crizotinib and digoxin
Crizotinib's FDA label of July 22, 2025 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name crizotinib. The crizotinib label: “Avoid concomitant use of XALKORI with drugs that cause bradycardia.”
Check it at the source: the crizotinib FDA label on DailyMed (effective July 22, 2025, Pfizer Laboratories Div Pfizer Inc); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the crizotinib label say about digoxin?
Crizotinib label, drug interactionsAvoid concomitant use of XALKORI with drugs that cause bradycardia (e.g., beta-blockers, non-dihydropyridine calcium channel blockers, clonidine, and digoxin) [see Warnings and Precautions (5.4) ].
Crizotinib label, warnings and precautionsAvoid using XALKORI in combination with other medications known to cause bradycardia (e.g., beta-blockers, nondihydropyridine-calcium channel blockers, clonidine, and digoxin) to the extent possible. Monitor heart rate and blood pressure regularly.
Source: FDA drug label (Xalkori), NDA217581 (Pf Prism Cv), as published by Pfizer Laboratories Div Pfizer Inc, effective July 22, 2025 (SPL set 2a51b0de-47d6-455e-a94c-d2c737b04ff7), via openFDA; the full label on DailyMed
What does the digoxin label say about crizotinib?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name crizotinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Crizotinib | Digoxin | |
|---|---|---|
| Labeled for | Lung cancer | Heart failure, Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.133 per tablet 125 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once