What the FDA labels say about taking them together
Cortisone and fludrocortisone
Fludrocortisone's FDA label of October 29, 2024 names cortisone in its warnings section; the cortisone label PlainMeds reads does not name fludrocortisone. The fludrocortisone label: “Average and large doses of hydrocortisone or cortisone can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium.”
Check it at the source: the cortisone FDA label on DailyMed (effective June 6, 2025, Chartwell RX, LLC); the fludrocortisone FDA label on DailyMed (effective October 29, 2024, Zydus Lifesciences Limited).
What does the cortisone label say about fludrocortisone?
Cortisone's label (effective June 6, 2025) does not name fludrocortisone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cortisone Acetate), Chartwell RX, LLC, effective June 6, 2025 (SPL set cc158d11-f356-4696-8b73-5d2681dcbcf2), via openFDA; the full label on DailyMed
What does the fludrocortisone label say about cortisone?
Fludrocortisone label, warningsAverage and large doses of hydrocortisone or cortisone can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium.
Source: FDA drug label (Fludrocortisone acetate), Zydus Lifesciences Limited, effective October 29, 2024 (SPL set 6c4a7d2d-00a4-4d80-ab4c-2afd4e4f614e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cortisone | Fludrocortisone | |
|---|---|---|
| Labeled for | Osteoarthritis, Asthma, Allergies, Herpes and shingles, Leukemia, lymphoma and myeloma, Crohn's disease and ulcerative colitis | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.311 per tablet 0.1 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once