Colesevelam · larger labeled portfolio than Glipizide
SPL labels Colesevelam + Glipizide as minor; Colesevelam 14 / Glipizide 8 in that band.
Mechanism on file: Colesevelam can bind to glipizide in your digestive system, which stops the medicine from being absorbed into your body. This makes the glipizide less effective at controlling your blood sugar.
FDA SPL severity: Minor
Colesevelam + Glipizide · SPL mechanism field
Colesevelam can bind to glipizide in your digestive system, which stops the medicine from being absorbed into your body. This makes the glipizide less effective at controlling your blood sugar.
Minor band excerpt · Colesevelam with Glipizide
In studies assessing the effect of colesevelam on the pharmacokinetics of glipizide ER in healthy volunteers, reductions in glipizide AUC 0-∞ and C max of 12% and 13%, respectively were observed when colesevelam was co-administered with glipizide ER. When glipizide ER was administered 4 hours prior to colesevelam, there was no significant change in glipizide AUC 0-∞ or C max , -4% and 0%, respectively. Therefore, glipizide should be administered at least 4 hours prior to colesevelam to ensure that colesevelam does not reduce the absorption of glipizide.
Colesevelam · 15 SPL pairs (broader portfolio than Glipizide)
- Cyclosporine minor
- Estradiol minor
- Ethinyl Estradiol/Norgestimate minor
- Glimepiride minor
Glipizide · 8 minor + 8 total pairs
- Fluconazole minor
- Lovastatin minor
- Phenytoin minor
- Posaconazole minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.