Colchicine · more major-labeled pairs than Digoxin
SPL labels Colchicine + Digoxin as minor; Colchicine 15 / Digoxin 105 in that band.
Mechanism on file: Taking these two drugs together can increase the risk of a serious condition where muscle tissue breaks down.
FDA SPL severity: Minor
Colchicine + Digoxin · SPL mechanism field
Taking these two drugs together can increase the risk of a serious condition where muscle tissue breaks down.
Minor band excerpt · Colchicine with Digoxin
Other Lipid-Lowering Drugs: fibrates, gemfibrozil Digitalis Glycosides: digoxin P-gp substrate; rhabdomyolysis has been reported Coadministration of P-gp and/or CYP3A4 inhibitors (e.g., clarithromycin or cyclosporine) have been demonstrated to alter the concentration of colchicine.
Colchicine · 4 major-labeled pairs (vs Digoxin's 2)
- Azithromycin minor
- Cyclosporine minor
- Diltiazem minor
- Estradiol minor
Digoxin · 120 SPL pairs (broader portfolio than Colchicine)
- Acarbose minor
- Albuterol minor
- Amiodarone minor
- Atorvastatin minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.