What the FDA labels say about taking them together
Cobicistat and vincristine
Cobicistat's FDA label of February 10, 2026 names vincristine in its drug interactions section; the vincristine label PlainMeds reads does not name cobicistat. The cobicistat label: “… dasatinib and nilotinib prescribing information for dosing instructions. For vincristine and vinblastine, monitor for hematologic or gastrointestinal side effects.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the vincristine FDA label on DailyMed (effective February 17, 2026, Hospira, Inc.).
What does the cobicistat label say about vincristine?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: dasatinib nilotinib vinblastine vincristine; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ anticancer agents; Clinical Comment: A decrease in the dosage or an adjustment of the dosing interval of dasatinib or nilotinib may be necessary upon coadministration with TYBOST coadministered with atazanavir or darunavir. Consult the dasatinib and nilotinib prescribing information for dosing instructions. For vincristine and vinblastine, monitor for hematologic or gastrointestinal side effects.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the vincristine label say about cobicistat?
Vincristine's label (effective February 17, 2026) does not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (VinCRIStine Sulfate), Hospira, Inc., effective February 17, 2026 (SPL set b22e4c8e-dbe1-4d4b-a026-e1812974071c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Vincristine | |
|---|---|---|
| Labeled for | HIV | Leukemia, lymphoma and myeloma |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once