What the FDA labels say about taking them together
Cobicistat and salmeterol
Cobicistat's FDA label of February 10, 2026 names salmeterol in its drug interactions section; the salmeterol label PlainMeds reads does not name cobicistat. The cobicistat label: “Coadministration with salmeterol is not recommended and may result in increased risk of cardiovascular adverse events associated with salmeterol, including QT prolongation, palpitations, and sinus tachycardia.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the salmeterol FDA label on DailyMed (effective October 10, 2022, GlaxoSmithKline LLC).
What does the cobicistat label say about salmeterol?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Inhaled Beta Agonist: salmeterol; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ salmeterol; Clinical Comment: Coadministration with salmeterol is not recommended and may result in increased risk of cardiovascular adverse events associated with salmeterol, including QT prolongation, palpitations, and sinus tachycardia.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the salmeterol label say about cobicistat?
Salmeterol's label (effective October 10, 2022) does not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SEREVENT DISKUS), GlaxoSmithKline LLC, effective October 10, 2022 (SPL set 12d9728e-6b5c-4aee-bfb0-745e542ed2e4), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Salmeterol | |
|---|---|---|
| Labeled for | HIV | Asthma, COPD |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $6.74 per unit 50 mcg |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once