What the FDA labels say about taking them together
Cobicistat and risperidone
Cobicistat's FDA label of February 10, 2026 names risperidone in its drug interactions section; the risperidone labels PlainMeds reads (4) do not name cobicistat. The cobicistat label: “A decrease in the dose of antipsychotics that are metabolized by CYP3A or CYP2D6 may be needed upon coadministration.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the risperidone FDA label on DailyMed (effective May 28, 2026, Janssen Pharmaceuticals, Inc.).
What does the cobicistat label say about risperidone?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Other antipsychotics: e.g., perphenazine risperidone thioridazine; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ antipsychotic; Clinical Comment: A decrease in the dose of antipsychotics that are metabolized by CYP3A or CYP2D6 may be needed upon coadministration.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the risperidone label say about cobicistat?
Risperidone's label (effective May 28, 2026) and its 3 other brand-application labels do not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (RISPERDAL), Janssen Pharmaceuticals, Inc., effective May 28, 2026 (SPL set 7e117c7e-02fc-4343-92a1-230061dfc5e0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Risperidone | |
|---|---|---|
| Labeled for | HIV | Bipolar disorder, Schizophrenia |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.0368 per tablet 0.25 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once