What the FDA labels say about taking them together
Cobicistat and rifabutin
Cobicistat's FDA label of February 10, 2026 names rifabutin in its drug interactions section, and rifabutin's label names cobicistat too. The cobicistat label: “The recommended adult dosage regimen for rifabutin is 150 mg every other day. Monitor for rifabutin associated adverse reactions including neutropenia and uveitis.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the rifabutin FDA label on DailyMed (effective September 1, 2026, REMEDYREPACK INC.).
What does the cobicistat label say about rifabutin?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: rifabutin; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ rifabutin cobicistat: effects unknown darunavir: effects unknown atazanavir: effects unknown; Clinical Comment: The recommended adult dosage regimen for rifabutin is 150 mg every other day. Monitor for rifabutin associated adverse reactions including neutropenia and uveitis.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the rifabutin label say about cobicistat?
Rifabutin label, drug interactionsElvitegravir/Cobicistat 150/50 mg daily 300 mg daily Or 150 mg every other day Healthy subjects (12) No significant change in rifabutin pharmacokinetics.
Source: FDA drug label (Rifabutin), NDA050689 (Pfizer), as published by REMEDYREPACK INC., effective September 1, 2026 (SPL set 25a60937-cbbe-4a50-994f-2ce15203f589), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Rifabutin | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $8.14 per capsule 150 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once