What the FDA labels say about taking them together
Cobicistat and prednisolone
Cobicistat's FDA label of February 10, 2026 names prednisolone in its drug interactions section; the prednisolone labels PlainMeds reads (4) do not name cobicistat. The cobicistat label: “… suppression. Alternative corticosteroids including beclomethasone, prednisone, and prednisolone should be considered, particularly for long-term use.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the prednisolone FDA label on DailyMed (effective June 25, 2026, PAI Holdings, LLC dba PAI Pharma).
What does the cobicistat label say about prednisolone?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Corticosteroids: e.g., betamethasone budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone triamcinolone; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↓ cobicistat ↓ atazanavir ↓ darunavir ↑ corticosteroids; Clinical Comment: Coadministration with oral dexamethasone or other systemic corticosteroids that induce CYP3A may result in loss of therapeutic effect and development of resistance to atazanavir or darunavir. Consider alternative corticosteroids. …
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the prednisolone label say about cobicistat?
Prednisolone's label (effective June 25, 2026) and its 3 other brand-application labels do not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PrednisoLONE Sodium Phosphate), PAI Holdings, LLC dba PAI Pharma, effective June 25, 2026 (SPL set d1f937e7-fed5-4079-bd52-5d930b34ae9f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Prednisolone | |
|---|---|---|
| Labeled for | HIV | Anemia, Leukemia, lymphoma and myeloma, Multiple sclerosis, Osteoarthritis, Asthma, Allergies, Herpes and shingles, Crohn's disease and ulcerative colitis, Eczema (atopic dermatitis), Organ transplant rejection |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $4.72 per mL 1% eye drop |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once