What the FDA labels say about taking them together
Cobicistat and nortriptyline
Cobicistat's FDA label of February 10, 2026 names nortriptyline in its drug interactions section; the nortriptyline label PlainMeds reads does not name cobicistat. The cobicistat label: “When coadministering with SSRIs, TCAs, or trazodone, careful dose titration of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitoring for antidepressant …”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the nortriptyline FDA label on DailyMed (effective December 4, 2024).
What does the cobicistat label say about nortriptyline?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Antidepressants: Selective Serotonin Reuptake Inhibitors (SSRIs) e.g., paroxetine Tricyclic Antidepressants (TCAs) e.g., amitriptyline desipramine imipramine nortriptyline Other antidepressants: trazodone; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: SSRIs: effects unknown ↑ TCAs ↑ trazodone; Clinical Comment: When coadministering with SSRIs, TCAs, or trazodone, careful dose titration of the antidepressant to the desired effect, including using the lowest feasible initial or maintenance dose, and monitoring for antidepressant response are recommended.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the nortriptyline label say about cobicistat?
Nortriptyline's label (effective December 4, 2024) does not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (PAMELOR), SpecGx LLC, effective December 4, 2024 (SPL set e17dc299-f52d-414d-ab6e-e809bd6f8acb), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Nortriptyline | |
|---|---|---|
| Labeled for | HIV | Depression |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.113 per capsule 10 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once