What the FDA labels say about taking them together
Cobicistat and mexiletine
Cobicistat's FDA label of February 10, 2026 names mexiletine in its drug interactions section; the mexiletine label PlainMeds reads does not name cobicistat. The cobicistat label: “Clinical monitoring is recommended upon coadministration with antiarrhythmics.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the mexiletine FDA label on DailyMed (effective May 14, 2026, Macleods Pharmaceuticals Limited).
What does the cobicistat label say about mexiletine?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Other antiarrhythmics: e.g., amiodarone disopyramide flecainide mexiletine propafenone quinidine; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ antiarrhythmics; Clinical Comment: Clinical monitoring is recommended upon coadministration with antiarrhythmics.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the mexiletine label say about cobicistat?
Mexiletine's label (effective May 14, 2026) does not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Mexiletine Hydrochloride), Macleods Pharmaceuticals Limited, effective May 14, 2026 (SPL set a61a07f6-0b48-4dcd-ad42-5d90f6e69ab1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Mexiletine | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.222 per capsule 150 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once