What the FDA labels say about taking them together
Cobicistat and metoprolol
Cobicistat's FDA label of February 10, 2026 names metoprolol in its drug interactions section; the metoprolol labels PlainMeds reads (4) do not name cobicistat. The cobicistat label: “Clinical monitoring is recommended for coadministration with beta-blockers that are metabolized by CYP2D6.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the metoprolol FDA label on DailyMed (effective March 3, 2026, Melinta Therapeutics, LLC).
What does the cobicistat label say about metoprolol?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Beta-Blockers: e.g., metoprolol carvedilol timolol; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ beta-blockers; Clinical Comment: Clinical monitoring is recommended for coadministration with beta-blockers that are metabolized by CYP2D6.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the metoprolol label say about cobicistat?
Metoprolol's label (effective March 3, 2026) and its 3 other brand-application labels do not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (TOPROL XL), Melinta Therapeutics, LLC, effective March 3, 2026 (SPL set 496ddfaa-7c9c-4888-b747-a210249b367a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Metoprolol | |
|---|---|---|
| Labeled for | HIV | High blood pressure, Angina, Heart failure, Heart attack and coronary artery disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.085 per tablet 100 mg tablet |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once