What the FDA labels say about taking them together
Cobicistat and methadone
Cobicistat's FDA label of February 10, 2026 names methadone in its drug interactions section; the methadone labels PlainMeds reads (4) do not name cobicistat. The cobicistat label: “A dose adjustment for buprenorphine, buprenorphine/naloxone, or methadone may be needed.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the methadone FDA label on DailyMed (effective December 8, 2025, Epic Pharma, LLC).
What does the cobicistat label say about methadone?
Cobicistat label, drug interactionsA dose adjustment for buprenorphine, buprenorphine/naloxone, or methadone may be needed.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the methadone label say about cobicistat?
Methadone's label (effective December 8, 2025) and its 3 other brand-application labels do not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methadone Hydrochloride), Epic Pharma, LLC, effective December 8, 2025 (SPL set 6da7501b-b881-4bc7-891a-74214a00a3ac), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Methadone | |
|---|---|---|
| Labeled for | HIV | Pain, Opioid use disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.177 per tablet 10 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once