What the FDA labels say about taking them together
Cobicistat and ketoconazole
Cobicistat's FDA label of February 10, 2026 names ketoconazole in its drug interactions section; the ketoconazole label PlainMeds reads does not name cobicistat.
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the ketoconazole FDA label on DailyMed (effective January 28, 2026, E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC).
What does the cobicistat label say about ketoconazole?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Antifungals: itraconazole ketoconazole; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ itraconazole ↑ ketoconazole; Clinical Comment: Specific dosing recommendations are not available for coadministration with itraconazole or ketoconazole.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the ketoconazole label say about cobicistat?
Ketoconazole's label (effective January 28, 2026) does not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ketoconazole), E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC, effective January 28, 2026 (SPL set cad7c647-34a9-4e4e-83b3-8d78e58f588f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Ketoconazole | |
|---|---|---|
| Labeled for | HIV | Fungal infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.249 per gram 2% cream |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once