What the FDA labels say about taking them together
Cobicistat and itraconazole
Cobicistat's FDA label of February 10, 2026 names itraconazole in its drug interactions section, and itraconazole's label names cobicistat too. The itraconazole label: “Cobicistat Elvitegravir (ritonavir-boosted) Ritonavir Saquinavir (unboosted) Monitor for adverse reactions.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the itraconazole FDA label on DailyMed (effective July 13, 2026, Janssen Pharmaceuticals, Inc.).
What does the cobicistat label say about itraconazole?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Antifungals: itraconazole ketoconazole; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ itraconazole ↑ ketoconazole; Clinical Comment: Specific dosing recommendations are not available for coadministration with itraconazole or ketoconazole.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the itraconazole label say about cobicistat?
Itraconazole label, drug interactionsCobicistat Elvitegravir (ritonavir-boosted) Ombitasvir/Paritaprevir/Ritonavir with or without Dasabuvir Ritonavir Saquinavir (unboosted) Monitor for adverse reactions.
Tolsura label (Mayne Pharma Commercial LLC, April 23, 2025), drug interactionsCobicistat Elvitegravir (ritonavir-boosted) Ritonavir Saquinavir (unboosted) Monitor for adverse reactions.
Source: FDA drug label (Tolsura, NDA208901), Mayne Pharma Commercial LLC, effective April 23, 2025 (SPL set 306352d1-9d5a-49ad-b72d-893b99546861), via openFDA
Source: FDA drug label (SPORANOX), Janssen Pharmaceuticals, Inc., effective July 13, 2026 (SPL set a4d555fa-787c-40fb-bb7d-b0d4f7318fd0), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Itraconazole | |
|---|---|---|
| Labeled for | HIV | Fungal infections |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.910 per capsule 100 mg capsule |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once