What the FDA labels say about taking them together
Cobicistat and fentanyl
Cobicistat's FDA label of February 10, 2026 names fentanyl in its drug interactions section; the fentanyl labels PlainMeds reads (2) do not name cobicistat. The cobicistat label: “Careful monitoring of therapeutic and adverse effects of fentanyl is recommended with coadministration.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the fentanyl FDA label on DailyMed (effective March 6, 2026, Hikma Pharmaceuticals USA Inc.).
What does the cobicistat label say about fentanyl?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: fentanyl; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ fentanyl; Clinical Comment: Careful monitoring of therapeutic and adverse effects of fentanyl (including potentially fatal respiratory depression) is recommended with coadministration.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the fentanyl label say about cobicistat?
Fentanyl's label (effective March 6, 2026) and its 1 other brand-application label do not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Fentanyl Citrate), Hikma Pharmaceuticals USA Inc., effective March 6, 2026 (SPL set ce5db1c2-feb1-4ad2-847a-d02e865bd47e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Fentanyl | |
|---|---|---|
| Labeled for | HIV | Pain |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $1.79 per mL 100 mcg/2 mL vial |
| Shortage now | A presentation being discontinued | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once