What the FDA labels say about taking them together
Cobicistat and ethinyl estradiol/norgestimate
Ethinyl estradiol/norgestimate's FDA label of February 6, 2026 names cobicistat in its drug interactions section; the cobicistat label PlainMeds reads does not name ethinyl estradiol/norgestimate. The ethinyl estradiol/norgestimate label: “Human immunodeficiency virus (HIV)/Hepatitis C virus (HCV) protease inhibitors, non-nucleoside reverse transcriptase inhibitors, and HIV/AIDS medications containing strong inhibitors or inducers of CYP3A Significant …”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the ethinyl estradiol/norgestimate FDA label on DailyMed (effective February 6, 2026, Glenmark Pharmaceuticals Inc., USA).
What does the cobicistat label say about ethinyl estradiol/norgestimate?
Cobicistat's label (effective February 10, 2026) does not name ethinyl estradiol/norgestimate in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the ethinyl estradiol/norgestimate label say about cobicistat?
Ethinyl estradiol/norgestimate label, drug interactions… inhibitors (decrease [e.g., boceprevir and telaprevir]) or with non-nucleoside reverse transcriptase inhibitors (decrease [e.g., nevirapine] or increase [e.g., etravirine]) or with HIV/AIDS medications containing strong inhibitors (e.g., cobicistat and ritonavir) or inducers of CYP3A.
Source: FDA drug label (Norgestimate and Ethinyl Estradiol), Glenmark Pharmaceuticals Inc., USA, effective February 6, 2026 (SPL set 8b247e46-203e-4f5b-b5a7-cbd57341c735), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Ethinyl estradiol/norgestimate | |
|---|---|---|
| Labeled for | HIV | Acne, Birth control |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.115 per tablet 0.25-0.035 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once