What the FDA labels say about taking them together
Cobicistat and erythromycin
Cobicistat's FDA label of February 10, 2026 names erythromycin in its drug interactions section; the erythromycin labels PlainMeds reads (4) do not name cobicistat.
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the erythromycin FDA label on DailyMed (effective August 1, 2024, Teva Pharmaceuticals USA, Inc.).
What does the cobicistat label say about erythromycin?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Antibacterials (macrolide or ketolide antibiotics): clarithromycin erythromycin telithromycin; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ clarithromycin ↑ erythromycin ↑ telithromycin ↑ cobicistat ↑ atazanavir ↑ darunavir; Clinical Comment: Consider alternative antibiotics with concomitant use of TYBOST coadministered with atazanavir or darunavir.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the erythromycin label say about cobicistat?
Erythromycin's label (effective August 1, 2024) and its 3 other brand-application labels do not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Erythromycin), Teva Pharmaceuticals USA, Inc., effective August 1, 2024 (SPL set 75a0bd5a-d09f-483b-bfd8-f8343b149eb2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Erythromycin | |
|---|---|---|
| Labeled for | HIV | Bacterial infections, Acne |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $1.96 per tablet 250 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once