What the FDA labels say about taking them together
Cobicistat and elbasvir/grazoprevir
Elbasvir/grazoprevir's FDA label of March 13, 2026 names cobicistat in its drug interactions section; the cobicistat label PlainMeds reads does not name elbasvir/grazoprevir. The elbasvir/grazoprevir label: “Co-administration of cobicistat-containing regimens is not recommended.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the elbasvir/grazoprevir FDA label on DailyMed (effective March 13, 2026, Merck Sharp & Dohme LLC).
What does the cobicistat label say about elbasvir/grazoprevir?
Cobicistat's label (effective February 10, 2026) does not name elbasvir/grazoprevir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the elbasvir/grazoprevir label say about cobicistat?
Elbasvir/grazoprevir label, drug interactionsConcomitant Drug Class/Drug Name: Elvitegravir/ cobicistat/ emtricitabine/ tenofovir (disoproxil fumarate or alafenamide); Effect on Concentration ↓ = decrease, ↑ = increase: ↑ EBR ↑ GZR; Clinical Comment: Co-administration of cobicistat-containing regimens is not recommended.
Source: FDA drug label (ZEPATIER), Merck Sharp & Dohme LLC, effective March 13, 2026 (SPL set 164dc02a-9180-426a-b8b5-04ab39d2bbd4), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Elbasvir/grazoprevir | |
|---|---|---|
| Labeled for | HIV | Hepatitis C |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | n/a |
| Shortage now | A presentation being discontinued | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once