What the FDA labels say about taking them together
Cobicistat and edoxaban
Cobicistat's FDA label of February 10, 2026 names edoxaban in its drug interactions section; the edoxaban label PlainMeds reads does not name cobicistat. The cobicistat label: “TYBOST coadministered with atazanavir or darunavir: Due to potentially increased bleeding risk, dosing recommendations for coadministration of apixaban with TYBOST depends on the apixaban dose. …”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the edoxaban FDA label on DailyMed (effective July 10, 2025, Daiichi Sankyo Inc.).
What does the cobicistat label say about edoxaban?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Anticoagulants: Direct Oral Anticoagulants (DOACs) apixaban rivaroxaban betrixaban dabigatran edoxaban; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ apixaban; Clinical Comment: TYBOST coadministered with atazanavir or darunavir: Due to potentially increased bleeding risk, dosing recommendations for coadministration of apixaban with TYBOST depends on the apixaban dose. Refer to apixaban dosing instructions for coadministration with strong CYP3A and P-gp inhibitors in apixaban prescribing information.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the edoxaban label say about cobicistat?
Edoxaban's label (effective July 10, 2025) does not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SAVAYSA), Daiichi Sankyo Inc., effective July 10, 2025 (SPL set e77d3400-56ad-11e3-949a-0800200c9a66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Edoxaban | |
|---|---|---|
| Labeled for | HIV | Atrial fibrillation, Stroke prevention, Blood clots (DVT and PE) |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $15.51 per tablet 60 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once