What the FDA labels say about taking them together
Cobicistat and drospirenone
Cobicistat's FDA label of February 10, 2026 names drospirenone in its contraindications section; the drospirenone label PlainMeds reads does not name cobicistat. The cobicistat label: “Contraindicated with TYBOST coadministered with atazanavir only: Coadministration of atazanavir with drospirenone is contraindicated due to potential for drospirenone-associated hyperkalemia.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the drospirenone FDA label on DailyMed (effective August 27, 2026, Exeltis USA, Inc.).
What does the cobicistat label say about drospirenone?
Cobicistat label, contraindicationsSt. John's wort ( Hypericum perforatum ) Hormonal Contraceptives: drospirenone/ ethinyl estradiol Lipid-modifying Agents: lomitapide, lovastatin, simvastatin Non-nucleoside Reverse Transcriptase Inhibitor: nevirapine Phosphodiesterase-5 (PDE-5) Inhibitor: sildenafil when administered as Revatio ® for the treatment of pulmonary arterial hypertension Protease Inhibitor: indinavir Sedative/hypnotics triazolam, orally administered midazolam Coadministration with certain drugs for which altered plasma concentrations are associated with serious and/or life-threatening events or loss of therapeutic effect.
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: drospirenone/ethinyl estradiol; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: atazanavir: ↑ drospirenone; Clinical Comment: Contraindicated with TYBOST coadministered with atazanavir only: Coadministration of atazanavir with drospirenone is contraindicated due to potential for drospirenone-associated hyperkalemia.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the drospirenone label say about cobicistat?
Drospirenone's label (effective August 27, 2026) does not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (SLYND), Exeltis USA, Inc., effective August 27, 2026 (SPL set db32bc55-f295-4d87-9dbb-0a2f45573dcf), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Drospirenone | |
|---|---|---|
| Labeled for | HIV | Birth control |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $6.61 per tablet 4 mg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once