What the FDA labels say about taking them together
Cobicistat and cyclosporine
Cobicistat's FDA label of February 10, 2026 names cyclosporine in its drug interactions section; the cyclosporine labels PlainMeds reads (4) do not name cobicistat. The cobicistat label: “These immunosuppressant agents are metabolized by CYP3A. Therapeutic drug monitoring is recommended if coadministered.”
Check it at the source: the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.); the cyclosporine FDA label on DailyMed (effective August 10, 2026, Novartis Pharmaceuticals Corporation).
What does the cobicistat label say about cyclosporine?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Immuno-suppressants: cyclosporine everolimus sirolimus tacrolimus; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ immuno-suppressants; Clinical Comment: These immunosuppressant agents are metabolized by CYP3A. Therapeutic drug monitoring is recommended if coadministered.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
What does the cyclosporine label say about cobicistat?
Cyclosporine's label (effective August 10, 2026) and its 3 other brand-application labels do not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Neoral), Novartis Pharmaceuticals Corporation, effective August 10, 2026 (SPL set 94461af3-11f1-4670-95d4-2965b9538ae3), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cobicistat | Cyclosporine | |
|---|---|---|
| Labeled for | HIV | Organ transplant rejection, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $1.04 per unit 0.05% eye emulsion |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once