What the FDA labels say about taking them together
Clopidogrel and sertraline
Sertraline's FDA label of August 8, 2023 names clopidogrel in its drug interactions section; clopidogrel's label does not name sertraline itself but warns about its class (serotonin reuptake inhibitors). The sertraline label: “The concurrent use of an antiplatelet agent or anticoagulant with ZOLOFT may potentiate the risk of bleeding.”
Check it at the source: the clopidogrel FDA label on DailyMed (effective May 30, 2025, Sanofi-Aventis U.S. LLC); the sertraline FDA label on DailyMed (effective August 8, 2023, Viatris Specialty LLC).
What does the clopidogrel label say about sertraline?
Clopidogrel's label does not name sertraline itself; it warns about its class (serotonin reuptake inhibitors):
Clopidogrel label, drug interactionsSince selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs) affect platelet activation, the concomitant administration of SSRIs and SNRIs with clopidogrel may increase the risk of bleeding.
Clopidogrel label, drug interactionsDecreased exposure to clopidogrel. Consider use of parenteral antiplatelet agent. ( 7.3 ) Nonsteroidal anti-inflammatory drugs (NSAIDs), warfarin, selective serotonin and serotonin norepinephrine reuptake inhibitors (SSRIs, SNRIs):
Source: FDA drug label (Plavix), Sanofi-Aventis U.S. LLC, effective May 30, 2025 (SPL set de8b0b67-eb25-4684-83b5-7ad785314227), via openFDA; the full label on DailyMed
What does the sertraline label say about clopidogrel?
Sertraline label, drug interactionsDrugs that Interfere with Hemostasis (antiplatelet agents and anticoagulants) Clinical Impact: The concurrent use of an antiplatelet agent or anticoagulant with ZOLOFT may potentiate the risk of bleeding. Intervention: Inform patients of the increased risk of bleeding associated with the concomitant use of ZOLOFT and antiplatelet agents and anticoagulants. For patients taking warfarin, carefully monitor the international normalized ratio [See ]. Examples: aspirin, clopidogrel, heparin, warfarin
Source: FDA drug label (Sertraline Hydrochloride, NDA020990), Mylan Pharmaceuticals Inc., effective September 15, 2024 (SPL set 1a58062b-e635-431a-908d-2651c6a4a21c), via openFDA
Source: FDA drug label (Zoloft), Viatris Specialty LLC, effective August 8, 2023 (SPL set fda754f6-d0f3-4dce-a17a-927d64f912f7), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clopidogrel | Sertraline | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, Angina | Depression, Anxiety |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0472 per tablet 75 mg tablet | $0.0507 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once