What the FDA labels say about taking them together
Clopidogrel and icosapent
Icosapent's FDA label of July 9, 2026 names clopidogrel in its warnings and precautions section; the clopidogrel label PlainMeds reads does not name icosapent. The icosapent label: “The incidence of bleeding was greater in patients receiving concomitant antithrombotic medications, such as aspirin, clopidogrel, or warfarin.”
Check it at the source: the clopidogrel FDA label on DailyMed (effective May 30, 2025, Sanofi-Aventis U.S. LLC); the icosapent FDA label on DailyMed (effective July 9, 2026, Hikma Pharmaceuticals USA Inc.).
What does the clopidogrel label say about icosapent?
Clopidogrel's label (effective May 30, 2025) does not name icosapent in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Plavix), Sanofi-Aventis U.S. LLC, effective May 30, 2025 (SPL set de8b0b67-eb25-4684-83b5-7ad785314227), via openFDA; the full label on DailyMed
What does the icosapent label say about clopidogrel?
Icosapent label, warnings and precautionsThe incidence of bleeding was greater in patients receiving concomitant antithrombotic medications, such as aspirin, clopidogrel, or warfarin.
Source: FDA drug label (Icosapent Ethyl), Hikma Pharmaceuticals USA Inc., effective July 9, 2026 (SPL set e3d38d1d-fbe7-413d-849a-675e7dfa9b0a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clopidogrel | Icosapent | |
|---|---|---|
| Labeled for | Heart attack and coronary artery disease, Angina | High triglycerides |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0472 per tablet 75 mg tablet | $0.441 per capsule 1 gram capsule |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once