What the FDA labels say about taking them together
Clonazepam and ranitidine
Clonazepam's FDA label of December 1, 2025 names ranitidine in its drug interactions section; the ranitidine label PlainMeds reads does not name clonazepam. The clonazepam label: “Effect of Other Drugs on the Pharmacokinetics of Clonazepam Literature reports suggest that ranitidine, an agent that decreases stomach acidity, does not greatly alter clonazepam pharmacokinetics.”
Check it at the source: the clonazepam FDA label on DailyMed (effective December 1, 2025, H2-Pharma, LLC); the ranitidine FDA label on DailyMed (effective May 1, 2026, Amneal Pharmaceuticals of New York LLC).
What does the clonazepam label say about ranitidine?
Clonazepam label, drug interactionsEffect of Other Drugs on the Pharmacokinetics of Clonazepam Literature reports suggest that ranitidine, an agent that decreases stomach acidity, does not greatly alter clonazepam pharmacokinetics.
Source: FDA drug label (Klonopin), NDA017533 (Cheplapharm), as published by H2-Pharma, LLC, effective December 1, 2025 (SPL set cfa0d79a-843c-4b88-95a1-e9511d649ca1), via openFDA; the full label on DailyMed
What does the ranitidine label say about clonazepam?
Ranitidine's label (effective May 1, 2026) does not name clonazepam in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ranitidine), Amneal Pharmaceuticals of New York LLC, effective May 1, 2026 (SPL set b38a3332-5c54-453f-aeb7-070f830955c2), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonazepam | Ranitidine | |
|---|---|---|
| Labeled for | Seizures and epilepsy, Anxiety | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.0244 per tablet 1 mg tablet | n/a |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once