What the FDA labels say about taking them together
Clonazepam and divalproex
Divalproex's FDA label of March 31, 2026 names clonazepam in its drug interactions section; clonazepam's label does not name divalproex itself but warns about its class (Anti-seizure medicines).
Check it at the source: the clonazepam FDA label on DailyMed (effective December 1, 2025, H2-Pharma, LLC); the divalproex FDA label on DailyMed (effective March 31, 2026, AbbVie Inc.).
What does the clonazepam label say about divalproex?
Clonazepam's label does not name divalproex itself; it warns about its class (Anti-seizure medicines):
Clonazepam label, warningsSuicidal Behavior and Ideation Antiepileptic drugs (AEDs), including Klonopin, increase the risk of suicidal thoughts or behavior in patients taking these drugs for any indication.
Clonazepam label, warningsPatients treated with any AED for any indication should be monitored for the emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior.
Source: FDA drug label (Klonopin), NDA017533 (Cheplapharm), as published by H2-Pharma, LLC, effective December 1, 2025 (SPL set cfa0d79a-843c-4b88-95a1-e9511d649ca1), via openFDA; the full label on DailyMed
What does the divalproex label say about clonazepam?
Divalproex label, drug interactionsClonazepam The concomitant use of valproate and clonazepam may induce absence status in patients with a history of absence type seizures.
Source: FDA drug label (Depakote), AbbVie Inc., effective March 31, 2026 (SPL set 08a65cf4-7749-4ceb-6895-8f4805e2b01f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clonazepam | Divalproex | |
|---|---|---|
| Labeled for | Seizures and epilepsy, Anxiety | Bipolar disorder, Migraine, Seizures and epilepsy |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.0244 per tablet 1 mg tablet | $0.194 per tablet 500 mg tablet |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once