What the FDA labels say about taking them together
Clomipramine and phenobarbital
Clomipramine's FDA label of November 26, 2024 names phenobarbital in its drug interactions section; the phenobarbital labels PlainMeds reads (2) do not name clomipramine. The clomipramine label: “Administration of CMI has been reported to increase the plasma levels of phenobarbital, if given concomitantly.”
Check it at the source: the clomipramine FDA label on DailyMed (effective November 26, 2024); the phenobarbital FDA label on DailyMed (effective August 27, 2026).
What does the clomipramine label say about phenobarbital?
Clomipramine label, drug interactionsAdministration of CMI has been reported to increase the plasma levels of phenobarbital, if given concomitantly ( see CLINICAL PHARMACOLOGY, Interactions ).
Source: FDA drug label (CLOMIPRAMINE HYDROCHLORIDE), SpecGx LLC, effective November 26, 2024 (SPL set d7cee3fa-d05c-4702-8f75-f446627bdb49), via openFDA; the full label on DailyMed
What does the phenobarbital label say about clomipramine?
Phenobarbital's label (effective August 27, 2026) and its 1 other brand-application label do not name clomipramine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Phenobarbital), Chartwell RX, LLC, effective August 27, 2026 (SPL set 74428144-fb24-40a5-a670-3b876e2d116c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clomipramine | Phenobarbital | |
|---|---|---|
| Labeled for | n/a | Seizures and epilepsy |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.189 per capsule 25 mg capsule | $0.213 per tablet 100 mg tablet |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once