What the FDA labels say about taking them together
Clomipramine and digoxin
Clomipramine's FDA label of November 26, 2024 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name clomipramine. The clomipramine label: “… patients taking other drugs that are highly bound to protein (e.g., warfarin, digoxin) may cause an increase in plasma concentrations of these drugs, potentially resulting in adverse effects.”
Check it at the source: the clomipramine FDA label on DailyMed (effective November 26, 2024); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the clomipramine label say about digoxin?
Clomipramine label, drug interactionsBecause clomipramine hydrochloride capsules are highly bound to serum protein, the administration of clomipramine hydrochloride capsules to patients taking other drugs that are highly bound to protein (e.g., warfarin, digoxin) may cause an increase in plasma concentrations of these drugs, potentially resulting in adverse effects.
Source: FDA drug label (CLOMIPRAMINE HYDROCHLORIDE), SpecGx LLC, effective November 26, 2024 (SPL set d7cee3fa-d05c-4702-8f75-f446627bdb49), via openFDA; the full label on DailyMed
What does the digoxin label say about clomipramine?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name clomipramine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clomipramine | Digoxin | |
|---|---|---|
| Labeled for | n/a | Heart failure, Atrial fibrillation |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.189 per capsule 25 mg capsule | $0.133 per tablet 125 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once