What the FDA labels say about taking them together
Clarithromycin and cobicistat
Cobicistat's FDA label of February 10, 2026 names clarithromycin in its drug interactions section; the clarithromycin label PlainMeds reads does not name cobicistat.
Check it at the source: the clarithromycin FDA label on DailyMed (effective April 9, 2026, Solaris Pharma Corporation); the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.).
What does the clarithromycin label say about cobicistat?
Clarithromycin's label (effective April 9, 2026) does not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Clarithromycin), Solaris Pharma Corporation, effective April 9, 2026 (SPL set 4d42821d-ce7a-7d64-e063-6294a90a0875), via openFDA; the full label on DailyMed
What does the cobicistat label say about clarithromycin?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Antibacterials (macrolide or ketolide antibiotics): clarithromycin erythromycin telithromycin; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↑ clarithromycin ↑ erythromycin ↑ telithromycin ↑ cobicistat ↑ atazanavir ↑ darunavir; Clinical Comment: Consider alternative antibiotics with concomitant use of TYBOST coadministered with atazanavir or darunavir.
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Clarithromycin | Cobicistat | |
|---|---|---|
| Labeled for | Bacterial infections, Acid reflux and ulcers | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.466 per tablet 500 mg tablet | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once