What the FDA labels say about taking them together
Citalopram and esomeprazole
Esomeprazole's FDA label of March 19, 2024 names citalopram in its drug interactions (prescription label) section; the citalopram labels PlainMeds reads (2) do not name esomeprazole. The esomeprazole label: “Increased exposure of citalopram leading to an increased risk of QT prolongation.”
Check it at the source: the citalopram FDA label on DailyMed (effective October 9, 2023, Allergan, Inc.); the esomeprazole FDA label on DailyMed (effective March 19, 2024, Haleon US Holdings LLC).
What does the citalopram label say about esomeprazole?
Citalopram's label (effective October 9, 2023) and its 1 other brand-application label do not name esomeprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Celexa), NDA020822 (Abbvie), as published by Allergan, Inc., effective October 9, 2023 (SPL set 4259d9b1-de34-43a4-85a8-41dd214e9177), via openFDA; the full label on DailyMed
What does the esomeprazole label say about citalopram?
Esomeprazole label, drug interactions (prescription label)Citalopram Clinical Impact: Increased exposure of citalopram leading to an increased risk of QT prolongation. Intervention: Limit the dose of citalopram to a maximum of 20 mg per day. See prescribing information for citalopram.
Source: FDA drug label (Nexium 24HR), NDA204655 (Astrazeneca Lp), as published by Haleon US Holdings LLC, effective March 19, 2024 (SPL set 4513934d-0cf0-40fc-a348-b4e75a33b094), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Citalopram | Esomeprazole | |
|---|---|---|
| Labeled for | Depression | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.026 per tablet 10 mg tablet | $0.145 per capsule 20 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once