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What the FDA labels say about taking them together

Cisplatin and verapamil

Verapamil's FDA label (Verapamil Hydrochloride) of November 27, 2024 names cisplatin in its drug interactions section; the cisplatin label PlainMeds reads does not name verapamil. The verapamil label: “The absorption of verapamil can be reduced by the cyclophosphamide, oncovin, procarbazine, prednisone (COPP) and the vindesine, adriamycin, cisplatin (VAC) cytotoxic drug regimens.”

Check it at the source: the cisplatin FDA label on DailyMed (effective September 16, 2021, WG Critical Care, LLC); the verapamil FDA label on DailyMed (effective April 6, 2026, Zydus Pharmaceuticals (USA) Inc.).

What does the cisplatin label say about verapamil?

Cisplatin's label (effective September 16, 2021) does not name verapamil in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (CISplatin), NDA018057 (Hq Spclt Pharma), as published by WG Critical Care, LLC, effective September 16, 2021 (SPL set 2bf8d2fb-80c8-401d-8e9b-d58463f5e954), via openFDA; the full label on DailyMed

What does the verapamil label say about cisplatin?

Verapamil Hydrochloride label (Wilshire Pharmaceuticals, Inc., November 27, 2024), drug interactions

The absorption of verapamil can be reduced by the cyclophosphamide, oncovin, procarbazine, prednisone (COPP) and the vindesine, adriamycin, cisplatin (VAC) cytotoxic drug regimens.

Source: FDA drug label (Verapamil Hydrochloride, NDA020943), Wilshire Pharmaceuticals, Inc., effective November 27, 2024 (SPL set 5f665d08-e1e4-422a-88c2-d8834abf9e1a), via openFDA

Source: FDA drug label (Verapamil hydrochloride), Zydus Pharmaceuticals (USA) Inc., effective April 6, 2026 (SPL set e19ab8d8-dae5-489d-9805-7e7407bea06d), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

9Cisplatin generic labelers
43Verapamil generic labelers
CisplatinVerapamil
Labeled forn/aHigh blood pressure, Atrial fibrillation, Angina
Boxed warningYesNo
Pharmacy cost (NADAC)n/a$0.191 per tablet 180 mg tablet
Shortage nowNo current entryA presentation being discontinued

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?