What the FDA labels say about taking them together
Ciprofloxacin and zolpidem
Ciprofloxacin's FDA label of March 2, 2026 names zolpidem in its drug interactions section; the zolpidem labels PlainMeds reads (4) do not name ciprofloxacin. The ciprofloxacin label: “Zolpidem; Avoid Use; Co-administration with ciprofloxacin may increase blood levels of zolpidem, concurrent use is not recommended”
Check it at the source: the ciprofloxacin FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.); the zolpidem FDA label on DailyMed (effective August 15, 2022, Viatris Specialty LLC).
What does the ciprofloxacin label say about zolpidem?
Ciprofloxacin label, drug interactionsZolpidem; Avoid Use; Co-administration with ciprofloxacin may increase blood levels of zolpidem, concurrent use is not recommended
Ciprofloxacin label, warnings and precautionsCo-administration of CIPRO and other drugs primarily metabolized by CYP1A2 (for example, theophylline, methylxanthines, caffeine, tizanidine, ropinirole, clozapine, olanzapine and zolpidem), results in increased plasma concentrations of the co-administered drug and could lead to clinically significant pharmacodynamic adverse reactions of the co-administered drug [see Drug Interactions ( 7 ) and Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Cipro), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 888dc7f9-ad9c-4c00-8d50-8ddfd9bd27c0), via openFDA; the full label on DailyMed
What does the zolpidem label say about ciprofloxacin?
Zolpidem's label (effective August 15, 2022) and its 3 other brand-application labels do not name ciprofloxacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Edluar), Viatris Specialty LLC, effective August 15, 2022 (SPL set a32884d0-85b5-11de-8a39-0800200c9a66), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ciprofloxacin | Zolpidem | |
|---|---|---|
| Labeled for | Diarrhea, Urinary tract infections, Bacterial infections | Insomnia |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.123 per tablet 500 mg tablet | $0.0344 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once