What the FDA labels say about taking them together
Ciprofloxacin and sildenafil
Ciprofloxacin's FDA label of March 2, 2026 names sildenafil in its drug interactions section; the sildenafil labels PlainMeds reads (4) do not name ciprofloxacin. The ciprofloxacin label: “Sildenafil Use with caution Two-fold increase in exposure Monitor for sildenafil toxicity.”
Check it at the source: the ciprofloxacin FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.); the sildenafil FDA label on DailyMed (effective November 17, 2023, Viatris Specialty LLC).
What does the ciprofloxacin label say about sildenafil?
Ciprofloxacin label, drug interactionsSildenafil Use with caution Two-fold increase in exposure Monitor for sildenafil toxicity [see Clinical Pharmacology ( 12.3 ) ].
Source: FDA drug label (Cipro), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 888dc7f9-ad9c-4c00-8d50-8ddfd9bd27c0), via openFDA; the full label on DailyMed
What does the sildenafil label say about ciprofloxacin?
Sildenafil's label (effective November 17, 2023) and its 3 other brand-application labels do not name ciprofloxacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Viagra), Viatris Specialty LLC, effective November 17, 2023 (SPL set d905dc8d-917f-4ea3-a4ee-a1ecf6967d4e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ciprofloxacin | Sildenafil | |
|---|---|---|
| Labeled for | Diarrhea, Urinary tract infections, Bacterial infections | Erectile dysfunction, Pulmonary arterial hypertension |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.123 per tablet 500 mg tablet | $0.132 per tablet 100 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once