What the FDA labels say about taking them together
Ciprofloxacin and procainamide
Ciprofloxacin's FDA label of March 2, 2026 names procainamide in its warnings and precautions section; the procainamide label PlainMeds reads does not name ciprofloxacin. The ciprofloxacin label: “… pointes, and patients receiving Class IA antiarrhythmic agents (quinidine, procainamide), or Class III antiarrhythmic agents (amiodarone, sotalol), tricyclic antidepressants, macrolides, and antipsychotics.”
Check it at the source: the ciprofloxacin FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.); the procainamide FDA label on DailyMed (effective February 17, 2025, Caplin Steriles Limited).
What does the ciprofloxacin label say about procainamide?
Ciprofloxacin label, warnings and precautionsAvoid CIPRO in patients with known prolongation of the QT interval, risk factors for QT prolongation or torsade de pointes (for example, congenital long QT syndrome, uncorrected electrolyte imbalance, such as hypokalemia or hypomagnesemia and cardiac disease, such as heart failure, myocardial infarction, or bradycardia), and patients receiving Class IA antiarrhythmic agents (quinidine, procainamide), or Class III antiarrhythmic agents (amiodarone, sotalol), tricyclic antidepressants, macrolides, and antipsychotics.
Source: FDA drug label (Cipro), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 888dc7f9-ad9c-4c00-8d50-8ddfd9bd27c0), via openFDA; the full label on DailyMed
What does the procainamide label say about ciprofloxacin?
Procainamide's label (effective February 17, 2025) does not name ciprofloxacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Procainamide Hydrochloride), Caplin Steriles Limited, effective February 17, 2025 (SPL set fcaa5e9a-3c8a-4796-aa87-626268b6cf60), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ciprofloxacin | Procainamide | |
|---|---|---|
| Labeled for | Diarrhea, Urinary tract infections, Bacterial infections | n/a |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.123 per tablet 500 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once