What the FDA labels say about taking them together
Ciprofloxacin and pirfenidone
Pirfenidone's FDA label of July 22, 2025 names ciprofloxacin in its drug interactions section; the ciprofloxacin labels PlainMeds reads (3) do not name pirfenidone. The pirfenidone label: “DRUG INTERACTIONS Moderate (e.g., ciprofloxacin) and strong inhibitors of CYP1A2 (e.g., fluvoxamine) increase systemic exposure of ESBRIET and may alter the adverse reaction profile of ESBRIET.”
Check it at the source: the ciprofloxacin FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.); the pirfenidone FDA label on DailyMed (effective July 22, 2025, Laurus Labs Limited).
What does the ciprofloxacin label say about pirfenidone?
Ciprofloxacin's label (effective March 2, 2026) and its 2 other brand-application labels do not name pirfenidone in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cipro), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 888dc7f9-ad9c-4c00-8d50-8ddfd9bd27c0), via openFDA; the full label on DailyMed
What does the pirfenidone label say about ciprofloxacin?
Pirfenidone label, drug interactionsDRUG INTERACTIONS Moderate (e.g., ciprofloxacin) and strong inhibitors of CYP1A2 (e.g., fluvoxamine) increase systemic exposure of pirfenidone and may alter the adverse reaction profile of pirfenidone.
Source: FDA drug label (Esbriet, NDA208780), Legacy Pharma USA Inc., effective June 9, 2025 (SPL set 81f17f7d-cb04-4052-8682-dd3e330210ab), via openFDA
Source: FDA drug label (Pirfenidone), Laurus Labs Limited, effective July 22, 2025 (SPL set 29b0fd0e-5a2b-4da7-8524-177dc28bf55e), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ciprofloxacin | Pirfenidone | |
|---|---|---|
| Labeled for | Diarrhea, Urinary tract infections, Bacterial infections | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.123 per tablet 500 mg tablet | $0.685 per tablet 267 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once