What the FDA labels say about taking them together
Ciprofloxacin and methotrexate
Ciprofloxacin's FDA label of March 2, 2026 names methotrexate in its drug interactions section; the methotrexate labels PlainMeds reads (4) do not name ciprofloxacin. The ciprofloxacin label: “Methotrexate; Use with caution Inhibition of methotrexate renal tubular transport potentially leading to increased methotrexate plasma levels; Potential increase in the risk of methotrexate associated toxic reactions. …”
Check it at the source: the ciprofloxacin FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.); the methotrexate FDA label on DailyMed (effective May 27, 2026, Accord Healthcare Inc.).
What does the ciprofloxacin label say about methotrexate?
Ciprofloxacin label, drug interactionsMethotrexate; Use with caution Inhibition of methotrexate renal tubular transport potentially leading to increased methotrexate plasma levels; Potential increase in the risk of methotrexate associated toxic reactions. Therefore, carefully monitor patients under methotrexate therapy when concomitant CIPRO therapy is indicated.
Source: FDA drug label (Cipro), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 888dc7f9-ad9c-4c00-8d50-8ddfd9bd27c0), via openFDA; the full label on DailyMed
What does the methotrexate label say about ciprofloxacin?
Methotrexate's label (effective May 27, 2026) and its 3 other brand-application labels do not name ciprofloxacin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Methotrexate), Accord Healthcare Inc., effective May 27, 2026 (SPL set 874c7f43-a3be-4236-89cc-24c44e3c5813), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ciprofloxacin | Methotrexate | |
|---|---|---|
| Labeled for | Diarrhea, Urinary tract infections, Bacterial infections | Rheumatoid arthritis, Psoriasis, Leukemia, lymphoma and myeloma, Breast cancer |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.123 per tablet 500 mg tablet | $0.158 per tablet 2.5 mg tablet |
| Shortage now | No current entry | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once