What the FDA labels say about taking them together
Ciprofloxacin and cobimetinib
Cobimetinib's FDA label of July 29, 2026 names ciprofloxacin in its drug interactions section; the ciprofloxacin labels PlainMeds reads (3) do not name cobimetinib. The cobimetinib label: “If concurrent short term (14 days or less) use of moderate CYP3A inhibitors including certain antibiotics is unavoidable for patients who are taking COTELLIC 60 mg, reduce COTELLIC dose to 20 mg.”
Check it at the source: the ciprofloxacin FDA label on DailyMed (effective March 2, 2026, Bayer HealthCare Pharmaceuticals Inc.); the cobimetinib FDA label on DailyMed (effective July 29, 2026, Genentech, Inc.).
What does the ciprofloxacin label say about cobimetinib?
Ciprofloxacin's label (effective March 2, 2026) and its 2 other brand-application labels do not name cobimetinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cipro), Bayer HealthCare Pharmaceuticals Inc., effective March 2, 2026 (SPL set 888dc7f9-ad9c-4c00-8d50-8ddfd9bd27c0), via openFDA; the full label on DailyMed
What does the cobimetinib label say about ciprofloxacin?
Cobimetinib label, drug interactionsIf concurrent short term (14 days or less) use of moderate CYP3A inhibitors including certain antibiotics (e.g., erythromycin, ciprofloxacin) is unavoidable for patients who are taking COTELLIC 60 mg, reduce COTELLIC dose to 20 mg.
Source: FDA drug label (Cotellic), Genentech, Inc., effective July 29, 2026 (SPL set c387579e-cee0-4334-bd1e-73f93ac1bde6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ciprofloxacin | Cobimetinib | |
|---|---|---|
| Labeled for | Diarrhea, Urinary tract infections, Bacterial infections | n/a |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.123 per tablet 500 mg tablet | n/a |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once