What the FDA labels say about taking them together
Cimetidine and pramipexole
Pramipexole's FDA label of March 31, 2026 names cimetidine in its warnings and precautions section; the cimetidine label PlainMeds reads does not name pramipexole. The pramipexole label: “… and concomitant medications that increase pramipexole plasma levels (e.g., cimetidine).”
Check it at the source: the cimetidine FDA label on DailyMed (effective July 15, 2026, Mylan Pharmaceuticals Inc.); the pramipexole FDA label on DailyMed (effective March 31, 2026, Torrent Pharmaceuticals Limited).
What does the cimetidine label say about pramipexole?
Cimetidine's label (effective July 15, 2026) does not name pramipexole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Cimetidine), Mylan Pharmaceuticals Inc., effective July 15, 2026 (SPL set 06c0a509-026f-44e0-9975-a94a8de51d43), via openFDA; the full label on DailyMed
What does the pramipexole label say about cimetidine?
Pramipexole label, warnings and precautionsBefore initiating treatment with pramipexole dihydrochloride tablets, advise patients of the potential to develop drowsiness and specifically ask about factors that may increase the risk for somnolence with pramipexole dihydrochloride tablets such as the use of concomitant sedating medications or alcohol, the presence of sleep disorders, and concomitant medications that increase pramipexole plasma levels (e.g., cimetidine) [see Clinical Pharmacology ( 12.3 )].
Source: FDA drug label (Pramipexole Dihydrochloride), Torrent Pharmaceuticals Limited, effective March 31, 2026 (SPL set 60167d7c-469f-455a-a113-561841af5e59), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cimetidine | Pramipexole | |
|---|---|---|
| Labeled for | Acid reflux and ulcers | Parkinson's disease |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.236 per tablet 300 mg tablet | $0.0452 per tablet 0.25 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once