What the FDA labels say about taking them together
Cilostazol and esomeprazole
Esomeprazole's FDA label of March 19, 2024 names cilostazol in its drug interactions (prescription label) section; the cilostazol label PlainMeds reads does not name esomeprazole. The esomeprazole label: “Increased exposure of cilostazol and one of its active metabolites (3,4-dihydro-cilostazol).”
Check it at the source: the cilostazol FDA label on DailyMed (effective September 10, 2026, Apotex Corp.); the esomeprazole FDA label on DailyMed (effective March 19, 2024, Haleon US Holdings LLC).
What does the cilostazol label say about esomeprazole?
Cilostazol's label (effective September 10, 2026) does not name esomeprazole in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (cilostazol), Apotex Corp., effective September 10, 2026 (SPL set ceac1ae3-c343-28ca-c083-b748d21a15e6), via openFDA; the full label on DailyMed
What does the esomeprazole label say about cilostazol?
Esomeprazole label, drug interactions (prescription label)Cilostazol Clinical Impact: Increased exposure of cilostazol and one of its active metabolites (3,4-dihydro-cilostazol). Intervention: Consider reducing the dose of cilostazol to 50 mg twice daily. See prescribing information for cilostazol.
Esomeprazole Strontium label (R2 Pharma, LLC, September 22, 2016), drug interactionsOmeprazole, given in doses of 40 mg daily for one week to 20 healthy subjects in cross-over study, increased C max and AUC of cilostazol by 18% and 26% respectively.
Source: FDA drug label (Esomeprazole Strontium, NDA202342), R2 Pharma, LLC, effective September 22, 2016 (SPL set 3c916d32-f9e9-1d15-e054-00144ff88e88), via openFDA
Source: FDA drug label (Nexium 24HR), NDA204655 (Astrazeneca Lp), as published by Haleon US Holdings LLC, effective March 19, 2024 (SPL set 4513934d-0cf0-40fc-a348-b4e75a33b094), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cilostazol | Esomeprazole | |
|---|---|---|
| Labeled for | n/a | Acid reflux and ulcers |
| Boxed warning | Yes | No |
| Pharmacy cost (NADAC) | $0.132 per tablet 100 mg tablet | $0.145 per capsule 20 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once