What the FDA labels say about taking them together
Ciclesonide and cobicistat
Cobicistat's FDA label of February 10, 2026 names ciclesonide in its drug interactions section; the ciclesonide labels PlainMeds reads (2) do not name cobicistat. The cobicistat label: “Coadministration with oral dexamethasone or other systemic corticosteroids that induce CYP3A may result in loss of therapeutic effect and development of resistance to atazanavir or darunavir. …”
Check it at the source: the ciclesonide FDA label on DailyMed (effective February 28, 2025, Covis Pharma US, Inc); the cobicistat FDA label on DailyMed (effective February 10, 2026, Gilead Sciences, Inc.).
What does the ciclesonide label say about cobicistat?
Ciclesonide's label (effective February 28, 2025) and its 1 other brand-application label do not name cobicistat in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Alvesco), NDA021658 (Azurity), as published by Covis Pharma US, Inc, effective February 28, 2025 (SPL set 9f6112fb-78ef-43cf-8ae3-36370eb45468), via openFDA; the full label on DailyMed
What does the cobicistat label say about ciclesonide?
Cobicistat label, drug interactionsConcomitant Drug Class/Drug Name: Corticosteroids: e.g., betamethasone budesonide ciclesonide dexamethasone fluticasone methylprednisolone mometasone triamcinolone; Potential Effect ↑ = Increase, ↓ = Decrease, ↔ = No change: ↓ cobicistat ↓ atazanavir ↓ darunavir ↑ corticosteroids; Clinical Comment: Coadministration with oral dexamethasone or other systemic corticosteroids that induce CYP3A may result in loss of therapeutic effect and development of resistance to atazanavir or darunavir. Consider alternative corticosteroids. …
Source: FDA drug label (Tybost), Gilead Sciences, Inc., effective February 10, 2026 (SPL set 3784c35c-e87f-410c-900b-8fd6313c6010), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ciclesonide | Cobicistat | |
|---|---|---|
| Labeled for | Asthma, Allergies | HIV |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $42.97 per gram 160 mcg inhaler | n/a |
| Shortage now | No current entry | A presentation being discontinued |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once