Chlorthalidone and Azilsartan Interaction
Drug interaction information between Chlorthalidone and Azilsartan.
Chlorthalidone and Azilsartan have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Chlorthalidone and Azilsartan. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These drugs work in different ways to lower blood pressure, which can increase the risk of very low blood pressure and kidney problems.
What To Do
Your doctor should monitor your blood pressure and kidney function closely while you are taking these medications.
FDA Label Information
7 DRUG INTERACTIONS Renal clearance of lithium is reduced by diuretics, such as chlorthalidone increasing the risk of lithium toxicity ( 7 ) NSAIDS increase risk of renal dysfunction and interfere with antihypertensive effect ( 7 ) Dual inhibition of the renin-angiotensin system: Increased risk of renal impairment, hypotension, and hyperkalemia ( 7 ) Lithium: Increases in serum lithium concentrations and lithium toxicity ( 7 ) 7.1 Non-Steroidal Anti-Inflammatory Agents including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors) In patients who are elderly, volume-depleted (including...
Chlorthalidone Also Interacts With
- Norepinephrine minor
- Fosinopril minor
Frequently Asked Questions
Can I take Chlorthalidone and Azilsartan together?
This is a moderate interaction. Your doctor should monitor your blood pressure and kidney function closely while you are taking these medications.
How serious is the interaction between Chlorthalidone and Azilsartan?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Chlorthalidone and Azilsartan interact?
These drugs work in different ways to lower blood pressure, which can increase the risk of very low blood pressure and kidney problems.
Understanding the Chlorthalidone and Azilsartan Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Chlorthalidone belongs to the Thiazide-Like Diuretic class and Azilsartan belongs to the Angiotensin II Receptor Blocker (ARB) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These drugs work in different ways to lower blood pressure, which can increase the risk of very low blood pressure and kidney problems. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Chlorthalidone has 3 total documented interactions on file in this dataset, and Azilsartan has 3. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor your blood pressure and kidney function closely while you are taking these medications. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Chlorthalidone or Azilsartan based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.