What the FDA labels say about taking them together
Chlorpromazine and lithium
Chlorpromazine's FDA label of May 12, 2026 names lithium in its warnings section; the lithium labels PlainMeds reads (4) do not name chlorpromazine.
Check it at the source: the chlorpromazine FDA label on DailyMed (effective May 12, 2026, Amneal Pharmaceuticals NY LLC); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the chlorpromazine label say about lithium?
Chlorpromazine label, warningsAn encephalopathic syndrome (characterized by weakness, lethargy, fever, tremulousness and confusion, extrapyramidal symptoms, leukocytosis, elevated serum enzymes, BUN and FBS) has occurred in a few patients treated with lithium plus an antipsychotic.
Source: FDA drug label (CHLORPROMAZINE HYDROCHLORIDE), Amneal Pharmaceuticals NY LLC, effective May 12, 2026 (SPL set aa086a21-de85-4b03-af58-49b70acf8cf0), via openFDA; the full label on DailyMed
What does the lithium label say about chlorpromazine?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name chlorpromazine in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Chlorpromazine | Lithium | |
|---|---|---|
| Labeled for | Schizophrenia, Nausea and vomiting | Bipolar disorder |
| Boxed warning | Yes | Yes |
| Pharmacy cost (NADAC) | $0.552 per tablet 100 mg tablet | $0.104 per capsule 300 mg capsule |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once