What the FDA labels say about taking them together
Cetirizine and levocetirizine
Cetirizine's FDA label (Quzyttir) of March 4, 2026 names levocetirizine in its contraindications section, and levocetirizine's label names cetirizine too. The cetirizine label: “CONTRAINDICATIONS The use of QUZYTTIR is contraindicated in patients with a known hypersensitivity to cetirizine hydrochloride or any of its ingredients, levocetirizine, or hydroxyzine.”
Check it at the source: the cetirizine FDA label on DailyMed (effective August 7, 2026, GLENMARK THERAPEUTICS INC., USA); the levocetirizine FDA label on DailyMed (effective March 11, 2026, Chattem, Inc.).
What does the cetirizine label say about levocetirizine?
Quzyttir label (TerSera Therapeutics LLC, March 4, 2026), contraindicationsCONTRAINDICATIONS The use of QUZYTTIR is contraindicated in patients with a known hypersensitivity to cetirizine hydrochloride or any of its ingredients, levocetirizine, or hydroxyzine.
Source: FDA drug label (Quzyttir, NDA211415), TerSera Therapeutics LLC, effective March 4, 2026 (SPL set f33e859d-ebc9-4d4f-a57d-204c48760d20), via openFDA
Source: FDA drug label (Cetirizine HCl), GLENMARK THERAPEUTICS INC., USA, effective August 7, 2026 (SPL set 04b08c52-5390-4cdb-a9e7-fca81fffdc73), via openFDA; the full label on DailyMed
What does the levocetirizine label say about cetirizine?
Levocetirizine label, contraindications (prescription label)Patients with a known hypersensitivity to levocetirizine or any of the ingredients of levocetirizine dihydrochloride tablets or to cetirizine
Levocetirizine label, drug interactions (prescription label)There was a small decrease (~16%) in the clearance of cetirizine caused by a 400 mg dose of theophylline.
Levocetirizine label, warningsWarnings Do not use if you have kidney disease if you have ever had an allergic reaction to this product or any of its ingredients or to an antihistamine containing cetirizine Ask a doctor before use if you have ever had trouble urinating or emptying your bladder When using this product drowsiness may occur avoid alcoholic drinks alcohol, sedatives, and tranquilizers may increase drowsiness be careful when driving a motor vehicle or operating machinery Stop use and ask a doctor if you have trouble urinating or emptying your bladder an allergic reaction to this product occurs.
Xyzal label (Chattem, Inc., July 22, 2025), contraindicationsCONTRAINDICATIONS The use of XYZAL is contraindicated in: Patients with a known hypersensitivity to levocetirizine or any of the ingredients of XYZAL or to cetirizine ( 4.1 ) Patients with end-stage renal disease at less than 10 mL/min creatinine clearance or patients undergoing hemodialysis ( 4.2 ) Children 6 months to 11 years of age with renal impairment
Source: FDA drug label (Xyzal, NDA022064), Chattem, Inc., effective July 22, 2025 (SPL set 1673f7ff-0c7c-4403-86cf-c05eb1475222), via openFDA
Source: FDA drug label (Xyzal Allergy 24HR), Chattem, Inc., effective March 11, 2026 (SPL set 8be45c2a-1eca-4a00-81b9-f7babdbdcd41), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cetirizine | Levocetirizine | |
|---|---|---|
| Labeled for | Allergies | Allergies |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0613 per tablet 10 mg tablet | $0.0511 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once