What the FDA labels say about taking them together
Ceritinib and digoxin
Ceritinib's FDA label of December 15, 2025 names digoxin in its warnings and precautions section; the digoxin labels PlainMeds reads (3) do not name ceritinib. The ceritinib label: “Avoid using ZYKADIA in combination with other products known to cause bradycardia to the extent possible. Monitor heart rate and blood pressure regularly.”
Check it at the source: the ceritinib FDA label on DailyMed (effective December 15, 2025, Novartis Pharmaceuticals Corporation); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the ceritinib label say about digoxin?
Ceritinib label, warnings and precautionsAvoid using ZYKADIA in combination with other products known to cause bradycardia (e.g., beta-blockers, non-dihydropyridine calcium channel blockers, clonidine, and digoxin) to the extent possible. Monitor heart rate and blood pressure regularly.
Source: FDA drug label (ZYKADIA), Novartis Pharmaceuticals Corporation, effective December 15, 2025 (SPL set fff5d805-4ffd-4e8e-8e63-6f129697563e), via openFDA; the full label on DailyMed
What does the digoxin label say about ceritinib?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name ceritinib in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Ceritinib | Digoxin | |
|---|---|---|
| Labeled for | Lung cancer | Heart failure, Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.133 per tablet 125 mcg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once