What the FDA labels say about taking them together
Cephalexin and probenecid
Cephalexin's FDA label of December 31, 2020 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name cephalexin. The cephalexin label: “Monitor for hypoglycemia. Probenecid - The renal excretion of cephalexin is inhibited by probenecid.”
Check it at the source: the cephalexin FDA label on DailyMed (effective December 31, 2020, Teva Pharmaceuticals USA, Inc.); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the cephalexin label say about probenecid?
Cephalexin label, drug interactionsMonitor for hypoglycemia. ( 7.1 ) Probenecid - The renal excretion of cephalexin is inhibited by probenecid.
Source: FDA drug label (Cephalexin), Teva Pharmaceuticals USA, Inc., effective December 31, 2020 (SPL set 19307ff0-71de-477b-965d-ea243e5ede3a), via openFDA; the full label on DailyMed
What does the probenecid label say about cephalexin?
Probenecid's label (effective January 5, 2021) does not name cephalexin in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cephalexin | Probenecid | |
|---|---|---|
| Labeled for | Bacterial infections, Urinary tract infections | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.120 per capsule 500 mg capsule | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once