Ceftazidime/Avibactam and Probenecid Interaction
Drug interaction information between Ceftazidime/Avibactam and Probenecid.
Ceftazidime/Avibactam and Probenecid have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ceftazidime/Avibactam and Probenecid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid blocks the body's ability to move the antibiotic out of the blood and into the urine. This causes the antibiotic levels to stay too high for too long.
FDA Label Information
7 DRUG INTERACTIONS 7.1 Probenecid In vitro , avibactam is a substrate of OAT1 and OAT3 transporters which might contribute to the active uptake from the blood compartment, and thereby its excretion. As a potent OAT inhibitor, probenecid inhibits OAT uptake of avibactam by 56% to 70% in vitro and, therefore, has the potential to decrease the elimination of avibactam when co-administered. Because a clinical interaction study of AVYCAZ or avibactam alone with probenecid has not been conducted, co-administration of AVYCAZ with probenecid is not recommended [ see Clinical Pharmacology ( 12.3 ) ] .
Ceftazidime/Avibactam Also Interacts With
- Ceftazidime minor
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Cefuroxime moderate
Frequently Asked Questions
What SPL severity band is on file for Ceftazidime/Avibactam + Probenecid?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Ceftazidime/Avibactam's 2. In the moderate band specifically: Ceftazidime/Avibactam has 1; Probenecid has 12 (also Amoxicillin, Amoxicillin/Clavulanate, Cefuroxime, Cephalexin).
What mechanism field is on file for Ceftazidime/Avibactam and Probenecid?
Probenecid blocks the body's ability to move the antibiotic out of the blood and into the urine. This causes the antibiotic levels to stay too high for too long.
Probenecid carries more major-labeled pairs than Ceftazidime/Avibactam
SPL source-record counts only. This page's band is moderate · classes on file: Ceftazidime/Avibactam (Cephalosporin / Beta-Lactamase Inhibitor); Probenecid (Uricosuric Agent).
Probenecid has 2 major-labeled pairs vs Ceftazidime/Avibactam's 0. This page itself is in the moderate band, not the major band.
0 major · 1 moderate · 1 minor · 2 total
Ceftazidime/Avibactam has no other moderate-band peer in this dataset besides Probenecid.
2 major · 12 moderate · 23 minor · 37 total
- Other moderate peers for Probenecid
- Amoxicillin
- Amoxicillin/Clavulanate
- Cefuroxime
- Cephalexin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.