What the FDA labels say about taking them together
Avibactam/ceftazidime and probenecid
Avibactam/ceftazidime's FDA label of April 30, 2025 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name avibactam/ceftazidime. The avibactam/ceftazidime label: “As a potent OAT inhibitor, probenecid inhibits OAT uptake of avibactam by 56% to 70% in vitro and, therefore, has the potential to decrease the elimination of avibactam when co-administered.”
Check it at the source: the avibactam/ceftazidime FDA label on DailyMed (effective April 30, 2025, Allergan, Inc.); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the avibactam/ceftazidime label say about probenecid?
Avibactam/ceftazidime label, drug interactionsAs a potent OAT inhibitor, probenecid inhibits OAT uptake of avibactam by 56% to 70% in vitro and, therefore, has the potential to decrease the elimination of avibactam when co-administered.
Source: FDA drug label (AVYCAZ), NDA206494 (Abbvie), as published by Allergan, Inc., effective April 30, 2025 (SPL set d9c2803f-dc9c-4b19-b4a3-8303bc8c15fd), via openFDA; the full label on DailyMed
What does the probenecid label say about avibactam/ceftazidime?
Probenecid's label (effective January 5, 2021) does not name avibactam/ceftazidime in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Avibactam/ceftazidime | Probenecid | |
|---|---|---|
| Labeled for | Urinary tract infections | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once