What the FDA labels say about taking them together
Cefpodoxime and probenecid
Cefpodoxime's FDA label of July 30, 2026 names probenecid in its drug interactions section; the probenecid label PlainMeds reads does not name cefpodoxime. The cefpodoxime label: “Probenecid As with other beta-lactam antibiotics, renal excretion of cefpodoxime was inhibited by probenecid and resulted in an approximately 31% increase in AUC and 20% increase in peak cefpodoxime plasma levels.”
Check it at the source: the cefpodoxime FDA label on DailyMed (effective July 30, 2026, Sandoz Inc); the probenecid FDA label on DailyMed (effective January 5, 2021, Lannett Company, Inc.).
What does the cefpodoxime label say about probenecid?
Cefpodoxime label, drug interactionsProbenecid As with other beta-lactam antibiotics, renal excretion of cefpodoxime was inhibited by probenecid and resulted in an approximately 31% increase in AUC and 20% increase in peak cefpodoxime plasma levels.
Source: FDA drug label (Cefpodoxime Proxetil), Sandoz Inc, effective July 30, 2026 (SPL set 8519a9d8-7106-4545-bc58-859ee9a6708e), via openFDA; the full label on DailyMed
What does the probenecid label say about cefpodoxime?
Probenecid's label (effective January 5, 2021) does not name cefpodoxime in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Probenecid), Lannett Company, Inc., effective January 5, 2021 (SPL set ab497fd8-00c3-4364-b003-b39d21fbdf38), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cefpodoxime | Probenecid | |
|---|---|---|
| Labeled for | Bacterial infections | Gout |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $1.04 per tablet 100 mg tablet | $0.636 per tablet 500 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once