What the FDA labels say about taking them together
Cefotaxime and furosemide
Cefotaxime's FDA label of April 11, 2024 names furosemide in its drug interactions section; the furosemide labels PlainMeds reads (4) do not name cefotaxime.
Check it at the source: the cefotaxime FDA label on DailyMed (effective April 11, 2024, Hikma Pharmaceuticals USA Inc.); the furosemide FDA label on DailyMed (effective September 30, 2025, Validus Pharmaceuticals LLC).
What does the cefotaxime label say about furosemide?
Cefotaxime label, drug interactionsDrug Interactions As with other cephalosporins, cefotaxime may potentiate the nephrotoxic effects of nephrotoxic drugs such as aminoglycosides, NSAIDs and furosemide.
Source: FDA drug label (Cefotaxime), Hikma Pharmaceuticals USA Inc., effective April 11, 2024 (SPL set ed23b6bc-32c7-4c50-a53d-313ae78e5623), via openFDA; the full label on DailyMed
What does the furosemide label say about cefotaxime?
Furosemide's label (effective September 30, 2025) and its 3 other brand-application labels do not name cefotaxime in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lasix), Validus Pharmaceuticals LLC, effective September 30, 2025 (SPL set 2c9b4d8f-0770-482d-a9e6-9c616a440b1a), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Cefotaxime | Furosemide | |
|---|---|---|
| Labeled for | Bacterial infections | Heart failure, High blood pressure, Edema (fluid retention) |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.490 per mL 20 mg/2 mL vial |
| Shortage now | In shortage | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once